¶ Indiana Biobank |
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| 351 W. 10th Street, Indianapolis, IN 46202 Indianabiobank.org Contact: inbiobnk@iu.edu |
Academic | |
| Role(s) | Formed In 2010 and supported by funds from the Lilly Endowment and the Indiana CTSI Support discovery research including academic, nonprofit, and commercial research entities |
| Mission | Aid discovery research that may lead to better ways to treat and prevent diseases. The Indiana Biobank works towards this goal by providing researchers with the tools and resources they need to advance their research. These tools and resources include providing researchers with banked samples, custom prospective collections of samples to meet a researcher’s specific needs, sample collection kits, and repository infrastructure to support a larger coordinated collection. |
| History | 2010 formed Indiana Biobank 2014 started custom collection 2015 began infrastructure support services 2016 started kit production core 2019 began Precision Health Consent Initiative 2020 formed omics data warehouse |
| Org | Four-person management team with support from lab and IT teams Leadership: • Tatiana Foroud: Executive Dean for Research Affairs, IU School of Medicine and Scientific Director • Brooke Patz: Program Manager |
| Board | Formal board is not required; however, the Indiana Biobank maintains a scientific advisory board to review requests for sample/data and services |
| Finance | • Supported by funds from the Lilly Endowment and the Indiana CTSI • Funded by grants to researchers using the Indiana Biobank Infrastructure • Recharge for services also supports the funding of the Biobank |
| Data Sources | • Wide ranging data from the Indiana Network for Patient Care including over 8,000 variables encompassing clinical, laboratory, and outcomes data, mined in collaboration with Regenstrief Data Services • DNA is regularly banked from patients with over 50,000 samples banked to date and growing • Other sample types such as serum, plasma, RNA, PBMC, urine, saliva and tissues are collected by request. • All samples are linked to the INPC, and thus, de-identified data linked to samples can be provided to approved academic, commercial, and nonprofit researchers • Omics data including WES, GWAS, RNA seq as well as cytokine/chemokine and PBMC analyses data available by request to academic and nonprofit collaborators |
| Data Access | • De-Identified EMR data linked to biological samples is provided to approved researchers • Data sets are designed to meet a researcher’s specific needs; retrospective and prospective data from the time of sample collection is available • Samples and data go through a review process before access is approved • To gain approval for the use of de-identified samples and data, researchers must submit a proposal describing the planned use of the samples and data. |
| Tech Capabilities | Enhanced ability to link individuals across various data sets |
| Projects | • Precision Health Consent- collaboration with IU Health and IUSM to sample 300,000 IU Health patients over the next five years. To date, there have been over 10,000 samples collected in a year through this collaboration, which puts the Indiana Biobank at just over 50,000 (and growing) DNA samples available for broad sharing. • Provide infrastructure support to over 30 projects including multiple NIH, ISDH and DoD grants • Support more than 30 custom, prospective collections of samples each year for numerous commercial, academic, and nonprofit entities |
| Future Focus | • Opportunity to link biological samples to electronic medical record data to support research to better understand the causes of disease • Utilizing telephone and video consent along with the use of remnant samples to obtain large numbers of samples available for future research |
| Talent Development | No direct training/education programs IB does host multiple interns every year |
| Data Sharing Agreements | Many agreements in place; however, they are use case specific |
| Programs/ Publications | Reports are mostly internal, specific to the companies that work with the Indiana Biobank |